abstract：:Since most infectious microorganisms inevitably develop resistance to any agents used to combat them, there has been a constant need to produce improved, more potent, antimicrobials. At least in part, the emergence and spread of resistant organisms has been provoked by inappropriate over-use of antibacterials. In the ...

journal_title：International journal of antimicrobial agents

authors： Ball P

更新日期：2007-12-01 00:00:00

abstract：:A series of 32 piperazine-linked bisbenzamidines (and related analogues) were analysed for their in vitro and in vivo trypanocidal activity against a drug-sensitive strain of Trypanosoma brucei brucei and a drug-resistant strain of Trypanosoma brucei rhodesiense. The compounds showed similar potencies against both str...

journal_title：International journal of antimicrobial agents

authors： Huang TL,Bacchi CJ,Kode NR,Zhang Q,Wang G,Yartlet N,Rattendi D,Londono I,Mazumder L,Vanden Eynde JJ,Mayence A,Donkor IO

更新日期：2007-12-01 00:00:00

abstract：:The frequency of invasive fungal infections (IFIs) has increased over the last decade with the rise in at-risk populations of patients. The morbidity and mortality of IFIs are high and management of these conditions is a great challenge. With the widespread adoption of antifungal prophylaxis, the epidemiology of invas...

journal_title：International journal of antimicrobial agents

authors： Shao PL,Huang LM,Hsueh PR

更新日期：2007-12-01 00:00:00

abstract：:The purpose of this study was to investigate the influence of an antibiotic policy programme based on restriction of the empirical use of fluoroquinolones and ceftazidime on the susceptibilities of Gram-negative microorganisms in a general Intensive Care Unit (ICU). The epidemiology of infections caused by the predomi...

journal_title：International journal of antimicrobial agents

authors： Ntagiopoulos PG,Paramythiotou E,Antoniadou A,Giamarellou H,Karabinis A

更新日期：2007-10-01 00:00:00

abstract：:To assess the molecular basis of nalidixic acid and ciprofloxacin resistance in Helicobacter pullorum, the gyrA gene of H. pullorum CIP 104787T was sequenced. In addition, 9 isolates (2 susceptible to ciprofloxacin and resistant to nalidixic acid, 3 susceptible and 4 resistant to both antibiotics) were selected from 4...

journal_title：International journal of antimicrobial agents

authors： Pasquali F,Rossi M,Manfreda G,Zanoni R

更新日期：2007-09-01 00:00:00

abstract：:This study was conducted to characterise the pharmacokinetics and pharmacodynamics of cefepime in plasma and peritoneal fluid (PF). One gram of cefepime was administered to eight laparotomy patients and plasma and PF samples were collected at the end of 0.5 h infusion and every hour for 6 h. Drug concentrations were d...

journal_title：International journal of antimicrobial agents

authors： Ikawa K,Morikawa N,Hayato S,Ikeda K,Ohge H,Sueda T

更新日期：2007-09-01 00:00:00

abstract：:There is considerable debate over the contribution of virginiamycin use in animals to quinupristin/dalfopristin (Q/D) resistance in humans. In this study, the prevalence and mechanisms of streptogramin resistance in enterococci from animals and the environment were investigated. From 2000-2004, enterococci from sample...

journal_title：International journal of antimicrobial agents

authors： Jackson CR,Fedorka-Cray PJ,Barrett JB,Hiott LM,Woodley TA

更新日期：2007-07-01 00:00:00

abstract：:We report seven cases of infective endocarditis caused by USA300 methicillin-resistant Staphylococcus aureus (MRSA) at an urban, tertiary care, academic institution. Five strains were community associated and two were healthcare associated. All patients were injection drug users. Staphylococcus aureus isolates were ch...

journal_title：International journal of antimicrobial agents

authors： Haque NZ,Davis SL,Manierski CL,Vager D,Donabedian SM,Perri MB,Sabbagh R,Cheema F,Zervos MJ

更新日期：2007-07-01 00:00:00

abstract：:A point prevalence survey of antimicrobial prescribing was performed in 10 Scottish hospitals using the Glasgow Antimicrobial Audit Tool (GAAT). Appropriateness of the intravenous (IV) route was determined by an infectious diseases physician (IDP) and by a computerised algorithm. The IDP also estimated IV agent approp...

journal_title：International journal of antimicrobial agents

authors： Seaton RA,Nathwani D,Burton P,McLaughlin C,MacKenzie AR,Dundas S,Ziglam H,Gourlay Y,Beard K,Douglas E

更新日期：2007-06-01 00:00:00

abstract：:The effect of subinhibitory concentrations of amikacin and ciprofloxacin on the hydrophobicity and adherence to uroepithelial cells of Escherichia coli strains was investigated. The hydrophobicity of the tested strains was evaluated by the bacterial adherence to hydrocarbon-xylene test and by the salt aggregation test...

journal_title：International journal of antimicrobial agents

authors： Wojnicz D,Jankowski S

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVES:To compare the in vitro activity of linezolid with 12 other antimicrobials against 190 strains of the coryneform bacteria, including 60 strains of C. amycolatum, 30 of C. striatum, 30 of C. jeikeium, 10 of C. urealyticum, 20 of B. casei, 20 of D. hominis and 20 of T. otitidis. METHODS:Minimum inhibitory con...

journal_title：International journal of antimicrobial agents

authors： Gómez-Garcés JL,Alos JI,Tamayo J

更新日期：2007-06-01 00:00:00

abstract：:Rollout of antiretroviral therapy (ART) in resource-limited countries has been identified as a global public health priority. Human immunodeficiency virus (HIV) treatment in the industrialised world is routinely accompanied by regular virological monitoring. By contrast, the implementation of ART in resource-limited s...

journal_title：International journal of antimicrobial agents

authors： Gupta RK,Pillay D

更新日期：2007-05-01 00:00:00

abstract：:Over the past decade, non-fermenting Gram-negative bacteria have emerged as important opportunistic pathogens in the increasing population of patients who are immunocompromised by their disease or medical treatment. These bacteria are assisted by their ubiquitous distribution in the environment and have a propensity f...

journal_title：International journal of antimicrobial agents

authors： Enoch DA,Birkett CI,Ludlam HA

更新日期：2007-05-01 00:00:00

abstract：:In this study, topoisomerase mutations in ciprofloxacin-resistant and -susceptible Campylobacter jejuni were analysed by DNA sequencing. In certain ciprofloxacin-resistant C. jejuni, the mechanism of resistance was complex. The Thr86-Ala substitution in the GyrA protein appears to play a role in increasing the minimum...

journal_title：International journal of antimicrobial agents

authors： Kinana AD,Cardinale E,Bahsoun I,Tall F,Sire JM,Garin B,Boye CS,Dromigny JA,Perrier-Gros-Claude JD

更新日期：2007-04-01 00:00:00

abstract：:As shown in a previous study, the outcome of multidrug-resistant tuberculosis (MDR-TB) in France is not satisfactory (41% success rate). To improve the management and outcome of patients with MDR-TB, a prospective intervention study was carried out in 1998-1999 by National Reference Centre (NRC) staff. NRC staff conta...

journal_title：International journal of antimicrobial agents

authors： Uffredi ML,Truffot-Pernot C,Dautzenberg B,Renard M,Jarlier V,Robert J

更新日期：2007-04-01 00:00:00

abstract：:The international (non-USA) ZAAPS Program has accumulated 4 years of linezolid resistance surveillance results tracking infections caused by organisms with evolving resistance profiles. The major organism groups monitored were: Staphylococcus aureus and coagulase-negative staphylococci (including methicillin [oxacilli...

journal_title：International journal of antimicrobial agents

authors： Ross JE,Fritsche TR,Sader HS,Jones RN

更新日期：2007-03-01 00:00:00

abstract：:In this paper, we identified 95 Malassezia isolates by morphological and biochemical criteria and assessed the in vitro activity of fluconazole, itraconazole, ketoconazole and voriconazole by broth microdilution against these species using slightly modified Leeming-Notman medium. The Malassezia isolates were identifie...

journal_title：International journal of antimicrobial agents

authors： Miranda KC,de Araujo CR,Costa CR,Passos XS,de Fátima Lisboa Fernandes O,do Rosário Rodrigues Silva M

更新日期：2007-03-01 00:00:00

abstract：:The bacterial time-kill curves of azithromycin against four bacterial strains (Streptococcus pneumoniae/penicillin-intermediate, S. pneumoniae/penicillin-sensitive, Haemophilus influenzae and Moraxella catarrhalis) were determined by in vitro infection models. Eighteen different pharmacokinetic/pharmacodynamic models ...

journal_title：International journal of antimicrobial agents

authors： Treyaprasert W,Schmidt S,Rand KH,Suvanakoot U,Derendorf H

更新日期：2007-03-01 00:00:00

abstract：:Multidrug resistance in yeast results from overexpression of genes encoding drug efflux transporters owing to gain-of-function mutations in transcription factors regulating their expression. We have screened a library of synthetic compounds for modulators of drug resistance using the multidrug-resistant Saccharomyces ...

journal_title：International journal of antimicrobial agents

authors： Cernicka J,Kozovska Z,Hnatova M,Valachovic M,Hapala I,Riedl Z,Hajós G,Subik J

更新日期：2007-02-01 00:00:00

abstract：:The activity of amphotericin B, fluconazole, flucytosine, itraconazole and voriconazole was tested in vitro against 618 clinical Candida spp. isolates, using the broth microdilution or the disk diffusion method (voriconazole). Amphotericin B and voriconazole were the most potent antifungal agents assayed (100% of susc...

journal_title：International journal of antimicrobial agents

authors： Gualco L,Debbia EA,Bandettini R,Pescetto L,Cavallero A,Ossi MC,Schito AM,Marchese A

更新日期：2007-02-01 00:00:00

abstract：:The evolution of imipenem disk-diffusion susceptibility results of 2652 strains of Klebsiella pneumoniae and 7596 Escherichia coli isolated during the period 2000-2005 were analysed. Screening for production of metallo-beta-lactamases was performed using the EDTA-synergy method. The percentage rate of K. pneumoniae is...

journal_title：International journal of antimicrobial agents

authors： Papaparaskevas J,Pantazatou A,Stefanou I,Mela V,Galatidis N,Avlamis A

更新日期：2007-02-01 00:00:00

abstract：:We investigated the in vitro activity of various piperacillin and sulbactam combinations against Gram-negative bacterial isolates from Intensive Care Units (ICUs) in Taiwan. Antimicrobial susceptibility testing of 1030 bacterial isolates recovered from ICUs of nine major teaching hospitals was performed using the agar...

journal_title：International journal of antimicrobial agents

authors： Hung MN,Hsueh PR,Chang HT,Lee WS,Chou MY,Chen IS,Wang JH,Lin CF,Shyr JM,Ko WC,Wu JJ,Liu YC,Huang WK,Teng LJ,Liu CY,Luh KT

更新日期：2007-02-01 00:00:00

abstract：:Resistant mutants of Ureaplasma parvum were selected by serial passages of a susceptible strain in subinhibitory concentrations of different macrolides and related antibiotics (erythromycin, azithromycin, josamycin, quinupristin, quinupristin/dalfopristin, pristinamycin and telithromycin). Mechanisms of resistance wer...

journal_title：International journal of antimicrobial agents

authors： Pereyre S,Métifiot M,Cazanave C,Renaudin H,Charron A,Bébéar C,Bébéar CM

更新日期：2007-02-01 00:00:00

abstract：:D-Alanylgriseoluteic acid (AGA) is a potent antimicrobial phenazine compound produced by Pantoea agglomerans (Erwinia herbicola) Eh1087. Susceptibility tests against a range of microbes indicated that AGA had a broad spectrum of antimicrobial activity and was particularly active against Gram-positive pathogens. Compar...

journal_title：International journal of antimicrobial agents

authors： Giddens SR,Bean DC

更新日期：2007-01-01 00:00:00

abstract：:The importance of the amino acid sequence in the C-terminal domain of penicillin-binding protein 5 (PBP5) and the levels of PBP5 expression to ampicillin resistance of Taiwan clinical isolates of Enterococcus faecium were studied. Sequence data revealed the existence of 12 amino acid sequence variants within the C-ter...

journal_title：International journal of antimicrobial agents

authors： Hsieh SE,Hsu LL,Hsu WH,Chen CY,Chen HJ,Liao CT

更新日期：2006-12-01 00:00:00

abstract：:Surveillance initiatives to track Streptococcus pneumoniae resistance trends are important for understanding the current in vitro effectiveness of available antimicrobial agents. The antimicrobial susceptibility profiles of S. pneumoniae (n=1479 isolates) collected from 17 geographical areas across the USA (2003-2004)...

journal_title：International journal of antimicrobial agents

authors： Draghi DC,Jones ME,Sahm DF,Tillotson GS

更新日期：2006-12-01 00:00:00

abstract：:Until now, studies confirming the safety of glycopeptide restriction in the empirical treatment of prolonged fever and neutropenia included only nine children. In an open-label observational study, the use of teicoplanin in paediatric oncology patients was investigated. A period of unrestricted use (2001-2003) was com...

journal_title：International journal of antimicrobial agents

authors： Simon A,Gröger N,Wilkesmann A,Hasan C,Wiszniewsky G,Engelhart S,Kramer MH,Bode U,Ammann RA,Fleischhack G

更新日期：2006-11-01 00:00:00

abstract：:Between November 2001 and November 2004, 231 Escherichia coli isolates resistant to beta-lactam antibiotics were identified. In 14 isolates, bla(TEM-24) (2 isolates), bla(TEM-52) (5 isolates) and bla(TEM-26) (7 isolates) were identified. In 145 E. coli isolates with the same M13 fingerprinting profile and the same res...

journal_title：International journal of antimicrobial agents

authors： Brizio A,Vasco S,Gonçalves AR,Lito LM,Cristino JM,Salgado MJ,Duarte A

更新日期：2006-10-01 00:00:00

abstract：:Invasive aspergillosis of the central nervous system has a mortality rate exceeding 90%. We describe a 29-year-old woman with a medical history of chronic polyarthritis who developed a proven rhinocerebral Aspergillus fumigatus infection refractory to first-line treatment with liposomal amphotericin B. The patient res...

journal_title：International journal of antimicrobial agents

authors： Elter T,Sieniawski M,Gossmann A,Wickenhauser C,Schröder U,Seifert H,Kuchta J,Burhenne J,Riedel KD,Fätkenheuer G,Cornely OA

更新日期：2006-09-01 00:00:00

abstract：:In this study, the potency of DX-619, a novel des-fluoro(6)-quinolone agent, was compared with that of vancomycin (VCM) in a murine model of haematogenous bronchopneumonia infection caused by methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-intermediate S. aureus (VISA). The minimum inhibitory concent...

journal_title：International journal of antimicrobial agents

authors： Yanagihara K,Seki M,Izumikawa K,Higashiyama Y,Miyazaki Y,Hirakata Y,Tomono K,Mizuta Y,Tsukamoto K,Kohno S

更新日期：2006-09-01 00:00:00

abstract：:Changes in the indigenous vaginal microflora with uropathogenic bacteria can predispose women to frequently recurring bacterial cystitis. Lactobacilli used as probiotics have played an important role in preventing the colonization of pathogenic bacteria in the vagina. A prospective clinical pilot study was performed t...

journal_title：International journal of antimicrobial agents

authors： Uehara S,Monden K,Nomoto K,Seno Y,Kariyama R,Kumon H

更新日期：2006-08-01 00:00:00

abstract：:We investigated the spread of bla(OXA-51)-type beta-lactamase genes in 200 Acinetobacter spp. clinical strains isolated in Argentina from 1982 to 2005. bla(OXA-51)-type genes were present in all Acinetobacter baumannii isolates tested (n=194), whereas they were not detected in two Acinetobacter haemolyticus, two genom...

journal_title：International journal of antimicrobial agents

authors： Merkier AK,Centrón D

更新日期：2006-08-01 00:00:00

abstract：:The incidence of nosocomial infections (NIs) in our surgical intensive care unit was evaluated with special consideration of nosocomial urinary tract infections (NUTIs). The trial was a prospective, single-centre, 6-month cohort study. Infections according to CDC criteria, pathogens, devices, APACHE II scores, infecti...

journal_title：International journal of antimicrobial agents

authors： Wagenlehner FM,Loibl E,Vogel H,Naber KG

更新日期：2006-08-01 00:00:00

abstract：:This review will summarise the relevant pathophysiology of sepsis, the rationale for treatment with recombinant human activated protein C and the evidence for and against its use, and will provide evidence-based recommendations for its administration. ...

journal_title：International journal of antimicrobial agents

authors： Hughes M

更新日期：2006-08-01 00:00:00

abstract：:We studied an in vitro model of continuous venovenous haemofiltration to determine levofloxacin adsorption by polyacrylonitrile (PAN) filters. Four doses of levofloxacin (5, 25, 50 and 100 mg) were used, resulting in circulating concentrations of levofloxacin at 120 min of 3.56+/-0.14, 15.84+/-2.08, 31.42+/-1.95 and 5...

journal_title：International journal of antimicrobial agents

authors： Tian Q,Gomersall CD,Wong A,Leung P,Choi G,Joynt GM,Tan P,Lipman J

更新日期：2006-08-01 00:00:00

abstract：:Invasive aspergillosis occurs in a wide range of immunocompromised patients and is typically associated with an extremely poor prognosis. Caspofungin represents an additional therapeutic alternative to standard antifungal therapies in patients with suspected or confirmed invasive aspergillosis, as evidenced by a growi...

journal_title：International journal of antimicrobial agents

authors： Maertens J

更新日期：2006-06-01 00:00:00

abstract：:The epidemiology of invasive fungal infections is currently at a crucial stage. Potentially fatal fungal strains are emerging that are resistant to many commonly used antifungal agents. It is therefore important to recognize and minimize the major risk factors associated with infection. This paper summarizes the key e...

journal_title：International journal of antimicrobial agents

authors： Maschmeyer G

更新日期：2006-06-01 00:00:00

abstract：:A multiresistant strain of Morganella morganii was isolated from a patient affected by several severe pathologies. The isolate was found to be resistant to the following antimicrobials: ampicillin, nalidixic acid, cefalothin, cefoxitin, ceftriaxone, ciprofloxacin, chloramphenicol, streptomycin, erythromycin, gentamici...

journal_title：International journal of antimicrobial agents

authors： Rojas L,Vinuesa T,Tubau F,Truchero C,Benz R,Viñas M

更新日期：2006-06-01 00:00:00

abstract：:The mechanism(s) of resistance or decreased susceptibility to cefepime (FEP) and/or imipenem (IMP) in three consecutive isolates of Enterobacter aerogenes (Ea1, Ea2 and Ea3) cultured from bronchial aspirates of the same patient after treatment with ceftriaxone and FEP were studied. Identification was performed with th...

journal_title：International journal of antimicrobial agents

authors： Fernández-Cuenca F,Rodríguez-Martínez JM,Martínez-Martínez L,Pascual A

更新日期：2006-06-01 00:00:00

abstract：:The antibacterial effects of six inorganic antibacterial agents were assessed using broth dilution and agar dilution tests on six pathogenic bacteria associated with oral infectious diseases: Streptococcus mutans (ATCC 25175), S. mutans (Ingbritt), Actinomyces viscosus (ATCC 15987), Lactobacillus casei (ATCC 393), Sta...

journal_title：International journal of antimicrobial agents

authors： Fang M,Chen JH,Xu XL,Yang PH,Hildebrand HF

更新日期：2006-06-01 00:00:00